• 凌祥

    药剂系 特聘副研究员
    领域:新金属配合物药物
    联系电话:
    电子邮箱:lingxiang@cpu.edu.cn
    办公室:
    实验室:江宁校区学院实验楼428北
  • 1、教育经历
    (1) 2012/09-2017/07, 我校/哈佛医学院,联合培养博士
    (2) 2008/09-2012/07, 我校,学士
    2、工作经历
    (1) 2021/06-至今, 我校, 3499cc拉斯维加斯入口, 特聘副研究员
    (1) 新金属配合物药物
    (2) 病理结晶与生物矿化
    (3) 免疫稳态与调控
    1、科研项目
    (1)国家自然科学基金青年项目,81801814,工程化细胞外囊泡介导铂类前药-免疫检查点阻断剂纳米粒逆转顺铂耐药肿瘤的研究,2019-01 至 2021-12,21万元,结题,主持
    1. Ling, X.; Gong, D.; Shi, W.; Xu, Z.; Han, W.; Lan, G.; Li, Y.; Qin, W.; Lin, W. Nanoscale Metal-Organic Layers Detect Mitochondrial Dysregulation and Chemoresistance via Ratiometric Sensing of Glutathione and pH. Journal of the American Chemical Society 2021. DOI: 10.1021/jacs.0c11764. (IF = 14.612)
    2. Ling, X.; Han, W.; Jiang, X.; Chen, X.; Rodriguez, M.; Zhu, P.; Wu, T.; Lin, W. Point-source burst of coordination polymer nanoparticles for tri-modality cancer therapy. Biomaterials 2021. DOI: 10.1016/j.biomaterials.2021.120690. (IF = 10.317)
    3. Ling, X.; Jiang, X.; Li, Y.; Han, W.; Rodriguez, M.; Xu, Z.; Lin, W. Sequential Treatment of Bioresponsive Nanoparticles Elicits Antiangiogenesis and Apoptosis and Synergizes with a CD40 Agonist for Antitumor Immunity. ACS Nano 2020. DOI: 10.1021/acsnano.0c07132. (IF = 14.588)
    4. Ling, X.; Tu, J.; Wang, J.; Shajii, A.; Kong, N.; Feng, C.; Zhang, Y.; Yu, M.; Xie, T.; Bharwani, Z.; Aljaeid, B. M.; Shi, B.; Tao, W.; Farokhzad, O. C. Glutathione-responsive prodrug nanoparticles for effective drug delivery and cancer therapy. ACS Nano 2019, 13, (1), 357-370. (IF = 14.588)
    5. Xiong, F.; Ling, X. (Co-first); Chen, X.; Chen, J.; Tan, J.; Cao, W.; Ge, L.; Ma, M.; Wu, J. Pursuing Specific Chemotherapy of Orthotopic Breast Cancer with Lung Metastasis from Docking Nanoparticles Driven by Bioinspired Exosomes. Nano Letters 2019, 19 (5), 3256-3266. (IF = 11.238)
    6. Chen, X.; Ling, X. (Co-first); Zhao, L.; Xiong, F.; Hollett, G.; Kang, Y.; Barrett, A.; Wu, J. Biomimetic shells endow sub-50 nm nanoparticles with ultrahigh paclitaxel payloads for specific and robust chemotherapy. ACS Applied Materials & Interfaces 2018, 10 (40), 33976-33985. (IF = 8.758)
    7. Ling, X.; Chen, X.; Riddell, I. A.; Tao, W.; Wang, J.; Hollett, G.; Lippard, S. J.; Farokhzad, O. C.; Shi, J.; Wu, J. Glutathione-scavenging poly(disulfide amide) nanoparticles for the effective delivery of Pt(IV) prodrugs and reversal of cisplatin resistance. Nano Letters 2018, 18 (7), 4618-4625. (IF = 11.238)
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