• 徐晓莉

    药物化学系 副教授
    领域:创新药物分子发现及成药性研究
    联系电话:
    电子邮箱:xuxiao_li@126.com
    办公室:江宁校区学院实验楼513室
    实验室:江宁校区学院实验楼525D
  • 1、教育经历
    (1) 2009/09-2014/07, 我校, 药物化学,博士
    (2) 2005/09-2009/07, 我校,国家生命科学与技术人才培养基地,学士
    2、工作经历
    (1) 2017/07 至今, 我校, 3499cc拉斯维加斯入口, 教授
    (3) 2014/08-2017/07, 我校, 中3499cc拉斯维加斯入口 博士后
    3、学术荣誉
    2021/05,江苏省“青蓝工程”优秀骨干教师
    2019/08,3499cc拉斯维加斯入口“岛津青年学者”
    2019/01,第二十二届中国药学会-施维雅青年药物化学奖
    通过运用计算机辅助药物设计、化学生物学、药物化学等多学科交叉手段,基于针对蛋白伴侣系统及肿瘤免疫系统开展创新药物研发工作。
    1、科研项目
    (1)国家自然科学基金委员会,面上项目,82073766,基于STING的“开放-闭合”动态激活构象发现、设计新型STING激动剂及其在 肿瘤免疫治疗中的应用探索。2021-01 至 2024-12,56万元,在研,主持
    (2)国家自然科学基金委员会,面上项目,81872737,基于诱导Phe199位移变化策略选择性抑制热休克蛋白内质网亚型Grp94蛋白的药物发现及其应用探索, 2019-01 至 2022-12,56万元,在研,主持
    (3)我校中央业务高校原创探索项目,2632022YC05,cGAS-STING 信号传导的新机制发现与分子设计研究,2022-01 至 2024-12,40万元,在研,主持
    (4)江苏省自然科学基金,面上项目,基于STING动态激活构象设计、发现新型STING激动剂及其在肿瘤免疫治疗中的应用探索。2020-07 至 2023-06,10万元,在研,主持
    (5)国家自然科学基金青年基金项目,81502990,热休克蛋白Hsp90 C-端调控剂的发现、设计及其化学生物学研究,2016.01至2018.12,17.9万,结题,主持。
    (6)江苏省基础研究计划(自然科学基金)青年基金项目,BK20150691,基于化学和生物信息学技术的Hsp90 C-端调控剂的发现、优化和作用模式研究,2015.7-2018.6,20万,结题,主持。
    [1]. Qiangsheng Zhu, Nannan Chen, Xinjian Tian, Yeling Zhou, QiDong You*, and Xiaoli Xu* Hematopoietic Progenitor Kinase 1 in Tumor Immunology: A Medicinal Chemistry Perspective. J. Med. Chem. 2022, 65, 12, 8065–8090.
    [2]. Li Li, Nannan Chen, Dandan Xia, Shicheng Xu, Wei Dai, Yuanyuan Tong, Lei Wang, Zhengyu Jiang*, Qidong You*, Xiaoli Xu*.  Discovery of a covalent inhibitor of heat shock protein 90 with antitumor activity that blocks the co-chaperone binding via C-terminal modification. Cell Chemical Biology. 2021.28(10), 1446-1459.e6.
    [3]. Shicheng Xu, Anping Guo, Nan-nan Chen, Wei Dai, Huan-aoyu Yang, Wenqin Xie, Mengjie Wang, Qi-Dong You*, Xiao-Li Xu*. Design and synthesis of Grp94 selective inhibitors based on Phe199 induced fit mechanism and their anti-inflammatory effects. Eur. J. Med. Chem. 2021.223, 113604.
    [4] LeiWang, JingshengJiang, LixiaoZhang, QiuyueZhang, JianruiZhou,Li Li, Xiao-li Xu,* Qidong You*.Discovery and Optimization of Small Molecules Targeting theProtein-Protein Interaction of Heat Shock Protein 90 (Hsp90) and Cell Division Cycle 37 as Orally Active Inhibitors for the Treatment of Colorectal Cancer J. Med. Chem. 2020 63 (3), 1281-1297.
    [5]. Han Zhang,Qi-Dong You*,Xiao-Li Xu* Targeting Stimulator of Interferon Genes (STING): A Medicinal Chemistry Perspective J. Med. Chem.2020, 63 (8):3785-3816
    [6]. Li Li, Lei Wang, Qi-Dong You,* and Xiao-Li Xu* Heat Shock Protein 90 Inhibitors: An Update on Achievements, Challenges, and Future Directions. J. Med. Chem. 2020, 63, 5, 1798-1822. IF: 6.023.
    [7]. Fen Jiang, An-ping Guo, Jia-chen Xu, Qi-Dong You,*Xiao-Li Xu* Discovery of a Potent Grp94 Selective Inhibitor with Anti- Inflammatory Efficacy in a Mouse Model of Ulcerative Colitis. J. Med. Chem. 2018, 61, 9513−9533.
    [8]. Fen Jiang, Hui-Jie Wang, Yu-Hui Jin, Qiong Zhang, Zhi-Hui Wang, Jian-Min Jia,Fang Liu, Lei Wang,Qi-Chao Bao, Dong-Dong Li, Qi-Dong You,*and Xiao-Li Xu*.Novel Tetrahydropyrido[4,3-d]pyrimidines as Potent Inhibitors of Chaperone Heat Shock Protein 90. J. Med. Chem. 2016, 59, 10498-10519.
    [9]. Wang, L.1; Xu, X.1; Jiang, Z.*; You, Q.*, Modulation of protein fate decision by small molecules: targeting molecular chaperone machinery. 2020. Acta Pharm Sin B. 2020. 10(10):1904-1925.
    [10]. Xiao-li Xu, Ying-rui Yang, Xiao-fei Mo, Jin-lian Wei, Xiao-jin Zhang, You, Q. D* Design, synthesis, and evaluation of benzofuran derivatives as novel anti-pancreatic carcinoma agents via interfering the hypoxia environment by targeting HIF-1a pathway. Eur. J. Med. Chem., 2017, 137, 45-62.
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