• 杭太俊

    药物分析系 教授
    领域:现代药物分析研究
    联系电话:
    电子邮箱:hangtj@cpu.edu.cn
    办公室:江宁校区学院科研楼229室
    实验室:江宁校区学院科研楼222西
  • 1、教育经历
    (1) 1980/09-1984/06,南京大学,化学系,化学专业,学士
    (2) 1984/09-1987/06,南京大学,化学系,分析化学专业,硕士
    (3) 1991/08-1992/12,英国Strathclyde大学,药学系,访问学者
    (4) 1998/09-2002/06,我校,药物分析专业,博士
    2、工作经历
    1987/07至今,我校,3499cc拉斯维加斯入口,药物分析专业教师
    3、学术荣誉
    人民卫生出版社药学类专业用《药物分析》国家级规划教材主编
    《药物分析》国家双语示范课程和江苏省外国留学生英文精品课程负责人
    4、学术兼职
    药物分析杂志,副主编
    中国新药杂志,编委
    Journal of Pharmaceutical and Biomedical Analysis, 编委(Editorial Advisory Board)
    Journal of Pharmaceutical Analysis, 编委
    国家执业药师职业资格考试命审题专家
    (1) 药物分析关键技术研究
    (2) 药物质量评价研究
    1、科研项目
    (1)国家重点研发计划,毒品违法犯罪监测预警关键技术研究和应用示范(2018YFC0807400,子项目2.2常见毒品的痕量分析技术研),2018-07 至 2021-06,100万元,结题,子项目主持
    (2)国家自然科学基金(面上项目),含朱砂中药柏子养心丸毒性与安全性的体内外汞物质形态关联研究(81473176),2015.01至2018.12,80万元,结题,主持
    (3)国家自然科学基金(面上项目),基于体内砷形态分析的牛黄解毒片配伍机制研究(81173648),2012.01 至 2015.12,58万元,结题,主持
    (4)国家自然科学基金(面上项目),基于代谢组学及联用技术的雷公藤内酯药代动力学和毒性比较研究(30973931),2010.01 至 2012.12,30万元,结题,主持

    潜心药物分析教学和研究。在化学药品、中药和体内药物分析等领域均有研究探索。提出了中药的随行“指纹对照”质量分析与控制策略,探索出了中药的比较药代动力学研究思路。并针对丹参、苦参、黄杨、雷公藤和牛黄解毒片等多种传统中成药进行了质量、药效和安全相关的深入研究。
    [1].Wu W, Cheng R, Boucetta H, Xu L, Pan JR, Song M, Lu YT, Hang TJ. Differences in Multicomponent Pharmacokinetics, Tissue Distribution, and Excretion of Tripterygium Glycosides Tablets in Normal and Adriamycin-Induced Nephrotic Syndrome Rat Models and Correlations With Efficacy and Hepatotoxicity. Front Pharmacol. 2022 Jun 9;13:910923. doi: 10.3389/fphar.2022.910923.
    [2].Jiang J, Hu ZL, Boucetta H, Liu JM, Song M, Hang TJ, Lu YT. Identification of degradation products in flumazenil using LC-Q-TOF/MS and NMR: Degradation pathway elucidation. J Pharm Biomed Anal. 2022 Jun 5;215:114764. doi:10.1016/j.jpba.2022.114764.
    [3].Xu L, Wang Y, Wu DF, Sun FM, Di B, Xu H, Song M, Lu YT, Hang TJ. Identification and monitoring of fentanyls-related substances in east China sewage water samples by LC-MS for drug enforcement. Sci Total Environ. 2021 Nov 25;797:149109. doi: 10.1016/j.scitotenv.2021.149109.
    [4].Han X, Cheng FJ, Di B, Xu H, Song M, Hang TJ, Lu YT. Identification and characterization of new impurities in zopiclone tablets by LC-QTOF-MS. J Pharm Biomed Anal. 2021 May 30;199:114056. doi: 10.1016/j.jpba.2021.114056.
    [5].Lu YT, Hu ZL, Shao FX, Song M, Hang TJ. Simultaneous determination of tazarotene, clindamycin phosphate and their active metabolites in Bama mini-pig skin by LC-MS/MS: Application to the development of a tazarotene/clindamycin phosphate cream. J Chromatogr B Analyt Technol Biomed Life Sci. 2021 Jan 1;1162:122455. doi: 10.1016/j.jchromb.2020.122455.
    [6].Wang Y, Xu L, Lu YT, Sun FM, Wu DF, Wang JQ, Di B, Xu H, Hang TJ, Song M. Impurity profiling of alfentanil hydrochloride by liquid chromatography/quadrupole time-of-flight high-resolution mass spectrometric techniques for drug enforcement. Rapid Commun Mass Spectrom. 2020 Sep 30;34(18):e8847. doi: 10.1002/rcm.8847.
    [7].Lu YT, Guan R, Zheng JR, Hang TJ, Song M. Determination of clobetasol propionate, tazarotene and tazarotenic acid in Bama mini-pig skin by UPLC-MS/MS:Application to pharmacokinetic and drug-drug interaction studies. J Pharm Biomed Anal. 2020 Jul 15;186:113322. doi: 10.1016/j.jpba.2020.113322.
    [8].Lu YT, Qi WZ, Wang S, Song XN, Yang DY, Song M, Hang TJ. Toxicity and risk assessment of mercury exposures from cinnabar and Baizi Yangxin Pills based on pharmacokinetic and tissue distribution studies. J Ethnopharmacol. 2020 Mar 25;250:112489. doi: 10.1016/j.jep.2019.112489.
    [9].Lu YT, Qi WZ, Chen YF, Song M, Hang TJ. Separation and identification of process-related substances and degradation products in mycophenolate mofetil by liquid chromatography coupled with quadrupole-time of flight mass spectrometry. J Sep Sci. 2019 Aug;42(16):2650-2659. doi: 10.1002/jssc.201900402.
    [10].Lu P, Wang L, Song M, Hang TJ. Identification and characterization of related substances in pomalidomide by hyphenated LC-MS techniques. J Pharm Biomed Anal. 2015 Oct 10;114:159-67. doi: 10.1016/j.jpba.2015.05.018.
    [11].Su MX, Song M, Sun DZ, Zhao H, Gu X, Zhu L, Zhan XL, Xu ZN, Wen AD, Hang TJ. Determination of sinomenine sustained-release capsules in healthy Chinese volunteers by liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Mar 15;889-890:39-43. doi:10.1016/j.jchromb.2012.01.027.
    杭太俊 教授
    宋 敏 教授
    陆宇婷 副教授
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